Love and death: microglia, NLRP3 and the Alzheimer's brain

摘要：

Microglia were previously attributed to be vital brain guardians for neuronal survival and synaptic pruning during development as well as for the brain's fight against environmental pathogens.A new report in Nature by the Heneka,Latz and Golenbock groups,however,sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration.
Size is frequently equal to significance and beauty,but many good things come in small packages.Thus,one of the smallest populations of brain cells,microglia (named after the Greek micro,meaning "small" because their soma diameter is approximately 12 μm,and glia,meaning "glue") that only represent 5％-10％ of all cells in the central nervous system (CNS) were underappreciated for a long time.

所属期刊栏目：23

在线出版日期：2013-07-01（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：595-596