Death at the airway epithelium in asthma
Allergic asthma is an inflammatory disease of the airways in which epithelial cells,dendritic cells and innate lymphoid cells are increasingly implicated.Recent findings suggest that apoptotic cells are phagocytosed by airway epithelial cells in a Rac1-dependent manner and this leads to dampening of innate and adaptive immunity to allergens.
Allergic asthma is a chronic inflammatory disease of the airways,characterized by the infiltration of eosinophils,basophils and mast cells into the airway submucosa and airway smooth muscle.The immune response to inhaled allergens is characterized by an aberrant Th2 lymphocyte response that causes the features of asthma,through the production of IL-4,IL-5 and IL-13.Type 2 innate lymphocytes (ILC2s) are also known as nuocytes or natural helper cells and produce copious amounts ofIL-5,IL-9 and IL-13.
23
2013-07-01(万方平台首次上网日期,不代表论文的发表时间)
共2页
588-589