DNA sensing unchained
In two recent reports in Science,James Chen and colleagues provide compelling evidence that detection of cytosolic DNA triggers the production of a novel second messenger,cyclic GMP-AMP (cGAMP),which in turn activates a signaling pathway that induces type Ⅰ interferons (IFNs) in a STING-dependent manner.They further unravel a key role for a so far uncharacterized murine protein E330016A19 (human homolog:C6ORF150),now termed cGAMP synthetase (cGAS),to act as the DNA sensor that generates cGAMP.
23
2013-07-01(万方平台首次上网日期,不代表论文的发表时间)
共3页
585-587