Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling
Dear Editor,
The canonical Wnt/β-catenin signaling pathway orchestrates cell morphology,motility,proliferation and differentiation.This pathway plays important roles in embryogenesis,adult tissue homeostasis and tissue regeneration.Aberrant activation of the Wnt/β-catenin signaling pathway has been implicated in the development of a broad spectrum of tumors,while attenuation of this pathway contributes to a number of human diseases including osteoporosis,neurodegenerative diseases,diabetes and Joubert syndrome [1].The design of organic compounds that modulate Wnt/β-catenin signaling constitutes an interesting strategy for therapeutic intervention of this key pathway.Additionally,as the Wnt/β-catenin signaling pathway is critical for the maintenance of embryonic stem cells and multiple types of adult stem cells,agonists or antagonists of Wnt/β-catenin signaling may provide useful tools for the studies of stem cell self-renewal and differentiation,and tissue regeneration.
23
2013-07-24(万方平台首次上网日期,不代表论文的发表时间)
共4页
581-584