Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis

摘要：

Dear Editor,
Stem cell niche is a specialized microenvironment crucial for stem cell self-renewal.Drosophila testis contains two types of stem cells:germline stem cells (GSCs)and somatic cyst stem cells (CySCs),providing a good model for studying niche-stem cell interaction [1].At the apex of testis tube,non-mitotic somatic cells form a tightly folded structure called the hub.About 10 GSCs,each accompanied by 2 CySCs,make direct contact with the hub cells to form a rose-like structure (Supplementary information,Figure S1A).CySCs rely on the hub cells for niche signals,while GSCs are maintained by niche signals from both the hub cells and CySCs [1].

所属期刊栏目：23

资助基金：grants from the National Basic Research Program of China973 Program:2011CB943902,2010CB912101 and 2012CB945001;the National Natural Science Foundation of China30971647,30971646,31171414 and 31171394;the Strategic Priority Research Program of the Chinese Academy of Sciences XDA01010405 and XDA01010406 to YZ and LZ,who are scholars of the Hundred Talents Program of the Chinese Academy of Sciences

在线出版日期：2013-07-24（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：573-576