The conformational shifts of the voltage sensing domains between NavRh and NavAb
Dear Editor,Voltage sensing domains (VSDs),also known as voltage sensors,are electromechanical coupling devices that convert the membrane potential changes to the activation of voltage-gated ion channels.VSDs comprise four transmembrane segments (S1-S4),among which the S4 segment contains repeating positively charged residues (gating charges) that are exposed from the intracellular side to the extracellular milieus in response to membrane depolarization.A charge transfer center (CTC) that consists of two negatively charged residues and a conserved aromatic residue on the S2 segment was identified [1].The two negatively charged amino acids,namely Anl and An2,may sequentially interact with the gating charges to lower the energy barrier during voltage-dependent charge transfer (Supplementary information,Figure S1)[2].
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the Ministry of Science and Technology2009CB918802 and 2011CB910501;the National Natural Science Foundation of China91017011 and 31070644;funds from Tsinghua University
2013-05-02(万方平台首次上网日期,不代表论文的发表时间)
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444-447