Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14
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Dear Editor,
Karrikins and strigolactones (SL) are two classes of butenolide compounds that control many aspects of plant physiology.Karrikins,originally found in the smoke of forest fires,have the ability to stimulate seed germination [1].SL are endogenous plant hormones that mediate responses to low levels of soil nutrients,such as phosphate and nitrate [2].They promote root branching to increase nutrient uptake while inhibiting shoot branching to reduce nutrient demand.SL are also secreted from roots to stimulate symbiotic associations with arbuscular mycorrhizal fungi for increased nutrient uptake,signals that are exploited to induce seed germination in parasitic weeds,including Striga and Orobanche,which are major causes of crop losses [2].
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the Jay and Betty Van Andel Foundation,Amway;the National Natural Science Foundation of ChinaNSFC 91217311;US National Institute of Health R01GM102545.The atomic coordinates have been deposited in the Protein Data Bank with accession codes listed in Supplementary information,Table S1.We thank staff members at Shanghai Synchrotron Radiation Facility SSRF beamline BL17U and the Life Science Collaborati