Crystal structure of an LRR protein with two solenoids

摘要：

Dear Editor,
The leucine rich repeat (LRR) is a versatile protein motif (～20-30 amino acids) found in a variety of protein in all life forms.Tandem arrays of two or more repeats in an LRR domain form a structure similar to a horseshoeshaped solenoid.Largely by acting as scaffolds for protein-protein interactions,LRR domains participate in diverse biological processes [1,2],as exemplified by the large family of LRR-containing receptor like kinases (LRR-RLKs) in plants [3].Nearly all the known typical LRR structures comprise an N-terminal cap (LRRNT)and some of them have a C-terminal cap (LRRCT) as well,shielding the two ends of the conserved central LRR segment [1,2].An LRR domain is characterized by a repetitive sequence pattern rich in leucine residues.However,in some LRR proteins including some plant LRR-RLKs and mammalian Toll-like receptors (TLR7-9),the LRR repeats are interrupted by sequences of 30-70 residues termed island domain or non-LRR region.

所属期刊栏目：23

资助基金：JC was funded by the State Key Program of the National Natural Science Foundation of China31130063;the Ministry of Science and Technology of China2010CB835300

在线出版日期：2013-04-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：303-305