Microenvironment-mediated resistance to anticancer therapies

摘要：

Resistance to molecularly targeted therapies can result from genomic alterations in the tumor cells that reactivate oncogenic signaling.Less is known of tumor ceil-extrinsic mechanisms of resistance to targeted therapies.Two recent studies have identified HGF as a soluble factor capable of mediating resistance to BRAF and HER2 inhibitors in a paracrine manner.These new findings suggest an important role for the tumor microenvironment in mediating resistance to molecularly targeted therapies.

所属期刊栏目：23

在线出版日期：2013-04-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：179-181