PKR stirs up inflammasomes

摘要：

Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1;active caspase-1,in turn,matures the pro-inflammatory IL-1β family cytokines by cleaving their pro-forms into the biologically active cytokines.The upstream mechanisms leading to inflammasome activation,in particular for the NRLP3 inflammasome,remain poorly understood.Lu and colleagues identify a new function of Protein Kinase R (PKR) for activating the NLRP1,NLRP3,NLRC4 and AIM2 inflammasomes,thus identifying a potential new target for treating inflammasome-mediated diseases.

所属期刊栏目：23

在线出版日期：2013-04-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：168-170