Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones
Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer.In doing so,they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the initiation of therapy.
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2013-03-28(万方平台首次上网日期,不代表论文的发表时间)
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