PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes
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In zygotes,a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division,concomitantly with the appearance of modified forms of 5-methylcytosine.The adjacent maternal pronucleus and certain paternallyimprinted loci are protected from this process.Nakamura et al.recently clarified the molecular mechanism involved:PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9(H3K9me2),thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.
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NIH grant HD065812 and grant RM1-01729 from the California Institute of Regenerative Medicine;NIH grants R00HD055333 and DP2-OD-008646 and grants from the Ellison Medical Foundation and March of Dimes to SK.JK is supported by a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research