Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin

摘要：

Dear Editor,Adaptation of microtubules to the structural and functional complexities involves diverse post-translational modifications of tubulins,including acetylation,tyrosination,detyrosination,polyglycylation,polyglutamylation,palmitoylation,and phosphorylation.In particular,acetylation of α-tubulin affects the cell motility and plays an important role in neuronal migration and differentiation [1].Specifically,acetylation of Lys40 of α-tubulin has prominent impacts on polarized protein trafficking and hence protein transport by promoting the binding of dynein/dynactin and kinesin-1 motor complexes[2,3].

所属期刊栏目：22

资助基金：We thank the staff members at the Shanghai Synchrotron Radiation Facility;China for technical support in diffraction data collection.This work was supported by the Ministry of Science and Technology of China2011CB966301;the National Natural Science Foundation of China31221001;the Chinese Academy of SciencesKSCX2-EW-Q-1-03

在线出版日期：2013-03-15（万方平台首次上网日期，不代表论文的发表时间）

页数：共5页

页码：1707-1711