Versatility of the translational machinery during stress:changing partners to keep dancing
Cap-dependent translation is initiated by the binding of eIF4E to the cap structure at the 5′ end of mRNAs.During hypoxic stress,global translation decreases because eIF4E is inactivated.In a recent article in Nature,Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of eIF4E,which binds to target mRNAs in complex with a hypoxia-induced RNP.
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I thank Juan Valcárcel for critical comments on this manuscript.Work in my lab is supported by BFU2009-08243 and Consolider CSD2009-00080 from MICINN
2013-03-15(万方平台首次上网日期,不代表论文的发表时间)
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1634-1636