Releasing the break on X chromosome inactivation:Rnf12/RLIM targets REX1 for degradation
One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI).Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM,but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery.A recent study by Gontan et al.shows that Rnf12/RLIM targets REX1,an inhibitor of XCI,for proteasomal degradation,providing an answer to this question.
X chromosome
22
Q2-06
2012-12-28(万方平台首次上网日期,不代表论文的发表时间)
1524-1526