Indigestible mitochondria cause heartburn
The link between impaired autophagic flux (autophagus interruptus),damaged mitochondria,and myocardial inflammation has been further tightened with the recent paper by Oka and colleagues,in which failure to degrade mitochondrial DNA exacerbated myocardial inflammation in the context of pressure overload.Using mice with cardiac-specific deletion of the lysosomal DNase Ⅱ that were subjected to aortic banding,Otsu”s group showed that mitochondrial DNA accumulated in lysosomes and resulted in TLR9-dependent production of inflammatory cytokines.
mitochondrial DNA、pressure overload
22
Q2-06
2012-12-28(万方平台首次上网日期,不代表论文的发表时间)
1518-1520