Pull and push: Talin activation for integrin signaling
The inside-out signaling of integrins regulates the ligand-binding affinity of the cell surface receptors in response to changes in the environment for cell survival.The specific binding to the cytoplasmic tail of integrin”s β subunit by the intracellular protein talin is the key step of insideout signaling.A ”pull-push” mechanism has been proposed to explain how the PIP2-enriched membrane disrupts the dual auto-inhibition of the N-terminal talin-FERM domain by the C-terminal talin-rod domain such that activated talin-FERM can reach the β-tail for integrin activation.
cell survival
22
Q2-06
2012-12-28(万方平台首次上网日期,不代表论文的发表时间)
1512-1514