REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology

摘要：

A hallmark of the mammalian circadian timing system is synchronization of physiology and behavior,but when this synchronization is disturbed,chronic diseases such as metabolic syndrome and depression may develop.Three new studies show that nuclear receptors of the Rev-Erb family impact the circadian oscillator and its metabolic output and this can be modified with specific agonists.Hence,resynchronization of metabolic pathways by manipulation of the circadian oscillator using REVERB-specific agonists may represent a feasible therapeutic concept to target diseases rooted in a misaligned circadian system.

机标关键词：metabolic syndrome

所属期刊栏目：22

分类号：Q2(细胞生物学)

在线出版日期：2012-12-12（万方平台首次上网日期，不代表论文的发表时间）

页码：1319-1321