CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome?

摘要：

CUL4B,a member of the cullinRING ubiquitin ligase family,is frequently mutated in X-linked mental retardation (XLMR) patients.The study by Liu et al.showed that Cul4b plays an essential developmental role in the extra-embryonic tissues,while it is dispensable in the embryo proper during mouse embryogenesis.Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.

机标关键词：mental retardation、animal model

所属期刊栏目：22

分类号：Q2(细胞生物学)

在线出版日期：2012-11-16（万方平台首次上网日期，不代表论文的发表时间）

页码：1224-1226