K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites
Efficient DNA damage sensing and repair is crucial to preserve genomic integrity and failure to detect or repair DNA breaks can cause mutations,contributing to the formation of tumors.One key protein required for mediating DNA repair is the tumor suppressor 53BP1.Recent studies now demonstrate the crucial role of K48-1inked ubiquitination and protein degradation for 53BP1 recruitment at sites of DNA damage.
DNA damage、protein degradation、tumor suppressor、DNA repair
22
Q2(细胞生物学)
This work was funded by CIHRMOP-67070
2012-11-16(万方平台首次上网日期,不代表论文的发表时间)
1221-1223