Onconase downregulates microRNA expression through targeting microRNA precursors

摘要：

Dear Editor,
Onconase,the smallest member of RNase A super family that was isolated from oocytes or early embryos of the Northern Leopard Frog (Rana pipiens),has been granted as an orphan drug for the treatment of malignant mesothelioma by US FDA [1,2].It was also tested in clinical trials for patients with non-small-cell lung cancer,breast cancer,and renal cell cancer [2].Onconase is extremely stable with a Tm of～87 ℃,resists degradation by various proteases,and evades ribonulease inhibitors (RI) present in mammalian cell cytosol [3-5],which confers advantages to its application in cancer treatment.More importantly,onconase specifically induces apoptosis of cancer cells but has low cytotoxicity to their normal counterparts [2].

所属期刊栏目：22

资助基金：grants from the Ministry of Science and Technology of China2011CB811303,2012CB910802,2011CB966304;the National Natural Science Foundation of China30970621,31170754

在线出版日期：2013-03-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：1199-1202