The mechanisms of IDH mutations in tumorigenesis
Tumor-associated mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes result in the loss of normal catalytic activity,the production of α-ketoglutarate (α-KG),and gain of a new activity,the production of an oncometabolite,R2-hydroxylglutarate (R-2-HG).New evidence supports previous findings that R-2-HG acts as an antagonist of α-KG to competitively inhibit the activity of multiple α-KG-dependent dioxygenases,including both histones and DNA demethylases involved in epigenetic control of gene expression and cell differentiation,and also reveals an intriguing new facet of R2-HG in tumorigenesis.
22
2013-03-08(万方平台首次上网日期,不代表论文的发表时间)
共3页
1102-1104