Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells

摘要：

Dear Editor,The in vitro propagation (IVP) of animal spermatogonial stem cells (SSCs) provides materials for studying the mechanism of spermatogenesis and for developing novel animal transgenesis and human therapy.The IVP of SSCs is reported to be promoted by exogenous growth factors,among which the glial cell-derived neurotrophic factor (GDNF) has been recognized as the single essential one ”1,2”.FGF2,a prototypical member of the FGF family,has been reported to be required for the IVP of SSCs from some mouse strains ”2”.The single-copy FGF2 gene generates one low-molecular weight (LMW)and several high-molecular weight (HMW) protein isoforms as a result of alternative translation initiations.

机标关键词：spermatogonial stem cells、survival、neurotrophic factor、growth factors、as a result of、materials for、translation、IVP、essential、required、in vitro、family、novel、human、GDNF、LMW、FGF

所属期刊栏目：22

分类号：Q2(细胞生物学)

资助基金：the National Basic Research Program of China2006CB944004;the National Natural Science Foundation of China30300182;30871406

在线出版日期：2012-07-17（万方平台首次上网日期，不代表论文的发表时间）

页码：773-776