Defining the expressed breast cancer kinome
Protein kinases are arguably the most tractable candidates for development of new therapies to treat cancer.Deep sequencing of breast cancer cell lines indicates each express 375or so kinases,representing nearly 75% of the kinome.A rich network both downstream and upstream from key oncogenic kinases includes both tyrosine and serine/threonine kinases,giving plasticity and resiliency to the cancer cell kinome.Protein kinases have proven to be highly tractable candidates for development of new cancer therapies with over 130 kinase-specific inhibitors currently in Phase 1-3 clinical trials ” 1”.Approximately 518 protein kinases are encoded by the human genome,collectively referred to as the kinome.
protein kinases、development、cancer cell、clinical trials、breast cancer、human genome、cell lines、network、express、new、key
22
Q2(细胞生物学)
NIHgrant GM303024;UNC Breast Cancer SPORECA058223;the University Cancer Research Fund
2012-07-17(万方平台首次上网日期,不代表论文的发表时间)
620-623