Rejuvenating liver and pancreas through celltransdifferentiation

摘要：

Induced pluripotent stem cells (iPSCs) and the cell transdifferentiation technologies are providing powerful tools to generate patient-specific cells for research and therapeutic applications.Hepatocytes and pancreatic βcells are two endoderm-derived cell types drawing much attention due to their indispensable physiological functions and strong association with various diseases.Recent advances in hepatocyte and β cell transdifferentiation have provided valuable insights into how to regenerate and restore normal functions of liver and pancreas under pathological conditions.The discovery of iPSCs in 2006 has revoked the commandment that cell differentiation and lineage specification is an irreversible process,hence fundamentally changing the way we comprehend and study cell fate determination.An ultimate goal of regenerative medicine is built on the passion to produce healthy human cells for cell therapies.

机标关键词：human cells、irreversible process、cell differentiation、normal functions、stem cells、attention、research、provided、changing、passion、study、two

所属期刊栏目：22

分类号：Q2(细胞生物学)

在线出版日期：2012-07-17（万方平台首次上网日期，不代表论文的发表时间）

页码：616-619