Telomere length and iPSC re-programming: survival of the longest
A hallmark feature of pluripotent stem cells is the ability to proliferate indefinitely (immortal phenotype).Despite reactivation of telomerase during iPSC derivation,there exists considerable heterogeneity in telomere length amongst established iPSC cell lines.Both telomerase-dependent and -independent mechanisms have now been shown to be important for continuous self-renewal of iPSC via the maintenance or extension of telomere length.The pluripotent stem cells that constitute the inner cell mass of the early blastocyst must have the capacity to go through many rounds of cell division to allow completion of embryonic development.Not surprisingly,these embryonic stem cells exhibit long telomeres and the enzymatic complex telomerase,which functions to complete telomere replication,is present at relatively high levels ”1,2”.
iPSC、telomerase、embryonic stem cells、inner cell mass、cell division、maintenance、completion、complex、levels、during、long、high、via
22
Q2(细胞生物学)
2012-07-17(万方平台首次上网日期,不代表论文的发表时间)
614-615