The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation
Dear Editor,Nuclear factor(NF)-κB is a family of transcription factors,which are critically involved in regulation of divergent physiological and pathological processes,such as apoptosis,tumorigenesis and immune response.The NF-κ3 family consists of five members,p65(RelA),RelB,c-Rel,pl00(the precursor of p52)and p105(the precursor of p50).The combinations between them produce a series of homodimers and heterodimers,such as p65:p50,c-Rel:p50,p50:p50,and so on,which play central roles in transcriptional regulation of genes involved in a wide range of functions from adaptive and innate immune responses to development of immune cells”1,2”.
ubiquitin、transcriptional regulation、pathological processes、transcription factors、immune responses、p50、immune cells、family、development、c-Rel、range of、central、RelB、RelA
22
Q2(细胞生物学)
2012-06-28(万方平台首次上网日期,不代表论文的发表时间)
603-606