CTCF:from insulators to alternative splicing regulation
The zinc-finger DNA-binding protein CTCF has been known for being a constituent of insulators.A recent paper in Nature reports an unforeseen intragenic role for CTCF that links DNA methylation with alternative splicing.By binding to its target DNA site placed within an alternative exon,CTCF creates a roadblock to transcriptional elongation that favors inclusion of the exon into mature mRNA.DNA methylation prevents CTCF binding,which releases pol Ⅱ transient blockage and promotes exon exclusion.
CTCF、regulation、DNA methylation、DNA-binding、paper in、Nature
22
Q2(细胞生物学)
2012-06-28(万方平台首次上网日期,不代表论文的发表时间)
450-452