Induction of fibroblasts to neurons through adenoviral gene delivery

摘要：

Dear Editor,The direct conversion of mouse fibroblasts to neurons ”1” was developed while many scientists were interested in neuronal differentiation using induced pluripotent stem cells (iPSCs) ”2”.This direct reprogramming skips a pluripotent state,making patient- and/or disease-specific cell therapy much faster and more feasible.Recent reports have indicated that mouse or human fibroblasts could be directly converted to a number of different cell types,such as cardiomyocytes,blood progenitor cells,hepatocyte-like cells,neural progenitors and specific dopaminergic neurons ”3-9”.However,all of the studies in this field have employed the retroviral or lentiviral vector delivery system.

机标关键词：dopaminergic neurons、lentiviral vector、direct conversion、progenitor cells、stem cells、different、studies、neural、making、human

所属期刊栏目：22

分类号：Q2(细胞生物学)

资助基金：This work was supported by grants from the Ministry of Science and Technology of China2011CBA00400;the Chinese Academy of Sciences Hundred Talent Program and the Stem Cell ProgramXDA01020301;XDA01020305

在线出版日期：2012-04-20（万方平台首次上网日期，不代表论文的发表时间）

页码：436-440