Autophagy is required for self-renewal and differentiation of adult human stem cells

摘要：

Dear Editor,Patients receiving anticancer therapy usually suffer from side effects,such as loss of hair,epithelial barrier defects,and myelosuppression,which,however,are usually reversible when the therapy is discontinued.Although this clinical experience suggests that adult stem cells may survive such therapeutic interventions,the underlying molecular regulatory mechanisms are poorly understood.Such regulatory mechanisms also seem to protect adult stem cells from acquiring mutations,which could lead to additional tumorigenesis.

机标关键词：stem cells、human、anticancer therapy、side effects、experience、molecular、however、loss

所属期刊栏目：22

分类号：Q2(细胞生物学)

资助基金：the Swiss National Science Foundation310030_129640

在线出版日期：2012-04-20（万方平台首次上网日期，不代表论文的发表时间）

页码：432-435