K-Ras and mitochondria: Dangerous liaisons
It is well documented that the KRAS oncogene efficiently transforms non-malignant cells,and there is some evidence for the role of mitochondria in this process.Now Peng Huang and colleagues show that K-Ras induction results early on in mitochondria assuming the phenotype consistent with the so-called Warburg effect,i.e.,increased glycolysis and attenuated oxidative phosphorylation.Thus the K-Ras protein capable of swift induction of phenotypic changes typical of cancer cells,yet these changes are reversible,and for cells to irreversibly reach their full malignant potential a much longer K-Ras expression is required,implicating mitochondria in the longer-term effects of the oncogene.
malignant potential、K-Ras、cells、changes、KRAS oncogene、required、typical、results、reach
22
Q2(细胞生物学)
2012-04-20(万方平台首次上网日期,不代表论文的发表时间)
285-287