Axing Wnt signals
Wnt signaling is a highly conserved and context-dependent signal transduction pathway that belongs to the so-called morphogens.Wnt signals are instrumental during development,but also play a central role in tissue homeostasis.For instance,in the intestine Wnt signaling is crucial for both stem cell maintenance and proliferation in the transient amplifying compartment ” 1”.This Wnt-dependent stem cell regulatory role is observed in diverse adult tissues,but is not a general feature as Wnt signals can also drive differentiation of cells,such as mesenchymal stem cells (MSCs) ”2”.Wnt signaling can be divided into a canonical and a noncanonical pathway.The non-canonical pathway mainly mediates migration,while the canonical signals are mostly conveyed by β-catenin,a transcription factor that is actively repressed in the cytoplasm in the absence of Wnt signals.β-catenin levels are kept under control by a multi-protein complex composed of the tumor suppressor adenomatous polyposis coli (APC);two kinases,casein kinase 1 (CK1) and glycogen synthase kinase 3 beta (GSK3-β);and Axin2 that serves as a scaffold to hold the complex together.
signal transduction pathway、mesenchymal stem cells、Wnt、transcription factor、glycogen synthase、tumor suppressor、complex、catenin、maintenance、development、migration、control、central、levels、during、MSCs、beta、two、APC
22
Q2(细胞生物学)
2012-04-20（万方平台首次上网日期，不代表论文的发表时间）
9-11
