Argonaute-2 regulates the proliferation of adult stem cells in planarian

摘要：

Dear Editor,Planarian Schmidtea mediterranea has extraordinary regeneration capabilities due to the abundance of adult stem cells (ASCs) known as neoblasts,which make planarian a powerful in vivo system to study ASC biology ” 1 ”.The Argonaute (AGO) family proteins are defined by the presence of Piwi-Argonaute-Zwille (PAZ)) and PIWI domains ”2”,and mediate silencing via cleavage of mRNAs ”3” or inhibition of translation ”4”.The AGO family proteins fall into two subfamilies,one named after Arabidopsis Argonaute and the other after Drosophila PIWI ”5”.In most organisms investigated so far,PIWI proteins bind Piwi-interacting RNAs (piRNAs) and are functionally involved in the regulation of germ cells ”6,7”.By contrast,AGO proteins have distinct roles in the smallRNA-mediated gene silencing pathway.In Drosophila,AGO1 has been illustrated to be engaged in the miRNA pathway,while AGO2 plays an important role in the siRNA-mediated gene regulation ”4”.

机标关键词：gene regulation、gene silencing、family、capabilities、translation、stem cells、germ cells、AGO1、contrast、defined、study、plays、mRNAs、miRNA、make、ASCs、via、two、far

所属期刊栏目：21

分类号：Q2(细胞生物学)

资助基金：the Ministry of Science and Technology of China2007CB947002;2010CB945600;2011CB811304;National Natural Science Foundation of China30770457;30828006;30971231;30971615;Chinese Academy of SciencesXDA01040306;KSCX2-YW-R-096;KSCX2-YW-R-233;Shanghai Pujiang Program05PJ 14105

在线出版日期：2012-03-20（万方平台首次上网日期，不代表论文的发表时间）

页码：1750-1754