Active DNA demethylation by oxidation and repair
DNA methylation and demethylation are increasingly recognized as important epigenetic factors in both plants and animals.DNA methylation,which is catalyzed by DNA methyltransferases (DNMTs),is a relatively stable and heritable modification that controls gene expression,cellular differentiation,genomic imprinting,paramutation,transposon movement,X-inactivation,and embryogenesis ”1”.The methylation of cytosine to 5-methylcytosine (5mC) is an important example of DNA modification in animals and plants.This highlight concerns DNA demethylation mechanisms in mammals and whether they are similar to that in plants.
oxidation、DNA、gene expression、embryogenesis、movement、controls、factors
21
R329.2(人体形态学)
2012-03-20(万方平台首次上网日期,不代表论文的发表时间)
1649-1651