A lincRNA switch for embryonic stem cell fate

摘要：

Cumulative evidences have demonstrated that most of the non-repetitive genome in higher organisms are actively transcribed and surprisingly only a small percentage (＜ 20％) of transcripts are associated with genes that encode proteins ”1”.One of the emerging themes in the study of non-coding transcripts is large intergenic non-coding RNAs (lincRNAs),a class of large regulatory RNAs implicated in imprinting,dosage compensation,and transcriptional regulation ”2”.In light of recent discoveries revealing the flexibility of lincRNAs and their abilities to act as modular scaffolds for protein-chromatin interactions and to form spatially compact arrays of complexes ”3,4”,many would acknowledge that most lincRNAs act as sensors and integrators of a wide variety of regulated transcriptional responses and probably epigenetic events,which may have an impact on various human diseases.

机标关键词：transcriptional regulation、non-coding、interactions、variety、impact、would、study、small、light、human、class、form

所属期刊栏目：21

分类号：R329.2(人体形态学)

资助基金：NIH,NCI,DoD and the Prostate Cancer Foundation grants to M G Rosenfeld.Michael G Rosenfeld is a Howard Hughes Medical Institute Investigator;L Yang is the recipient of a DoD Era of Hope Postdoctoral AwardW81XWH-08-1-0554;C Lin is the recipient of a Susan G Komen for the Cure FellowshipKG080247

在线出版日期：2012-03-20（万方平台首次上网日期，不代表论文的发表时间）

页码：1646-1648