Prion-like behavior of MAVS in RIG-I signaling

摘要：

Viral infection triggers the innate antiviral response in part through activation of RIG-I,a cytoplasmic sensor of 5”-triphosphorylated and uncapped single- or double-stranded RNA,which are not found among endogenous selfRNA.RIG-I signaling depends on the function of mitochondrial antiviral signaling (MAVS) protein,an adapter that links RIG-I,and the related RNA sensor MDA5,to events leading to transcriptional activation by NF-κB and IRF3.In contrast to the cytoplasmic localization of other innate immune signaling adapters,MAVS is positioned at mitochondrial membranes ” 1 ”,and to a lesser extent at peroxisomal membranes ”2”,by virtue of a C-terminal transmembrane domain.

机标关键词：function、contrast、related、adapter、RNA、found

所属期刊栏目：21

分类号：Q2(细胞生物学)

在线出版日期：2012-03-20（万方平台首次上网日期，不代表论文的发表时间）

页码：1643-1645