Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis
Dear Editor,Ever since the creation of induced pluripotent cells (iPSCs) from adult somatic cells by the ectopic expression of defined transcription factors ”1,2”,whether iPS cells are equivalent to embryonic stem cells (ESCs) in function and safety aspects has been a major concern regarding their potential applications.Previously,we and others have demonstrated that fully reprogrammed iPSCs were capable of producing full-term mice via the tetraploid complementation method ”3-5”,yet a thorough postnatal development evaluation of iPS mice is still lacking.
ES cells、developmental features、iPS、development evaluation、transcription factors、embryonic stem cells、somatic cells、mice、function、defined、aspects、major、fully、via
21
Q2(细胞生物学)
2012-01-18(万方平台首次上网日期,不代表论文的发表时间)
1634-1637