Putting muscle in DNA methylation
Over 25 years ago seminal experiments from the labs of Peter Jones and Harold Weintraub demonstrated that alteration in the DNA modification state underlie the myogenic conversion of fibroblast cell lines ”1,2”.This paved the way for the identification of myogenic helix-loop-helix (HLH) proteins in muscle differentiation,but the mechanism by which DNA methylation regulates muscle differentiation has remained elusive ”3”.
identification of、DNA methylation、cell lines、Harold、HLH、ago
21
Q2(细胞生物学)
2012-01-18(万方平台首次上网日期,不代表论文的发表时间)
1531-1533