Purging and isolating pluripotent cells, ”sweet” dreams become true?
The formation of an adult organism could be viewed as a hierarchical process in which the initial totipotent cell,the zygote,progressively loses ”potency” by differentiating into pluripotent,multipotent and unipotent states until the final terminally differentiated cells comprising tissues and organs are derived.Such a unidirectional concept trembled when four transcription factors were shown to ”revert” the identity of differentiated somatic cells and reprogram them into induced pluripotent stem cells (iPSCs) ”1”.
transcription factors、somatic cells、stem cells、identity、initial、final、four
21
Q2(细胞生物学)
2012-01-18(万方平台首次上网日期,不代表论文的发表时间)
1526-1527