LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization
Dear Editor,The LATS tumor suppressor,conserved from Drosophila (dlats) to humans (LATS1,LATS2),plays a vital role in maintaining cellular homeostasis in humans since loss of either LATS1 or LATS2 leads to the development of numerous cancer types such as breast cancer and leukemia ”1”.Apart from its roles as a Ser/Thr kinase within the emerging Hippo pathway regulating cell proliferation and apoptosis,ultimately leading to the control of organ size and tumorigenesis ”2”,LATS is also implicated in a broad range of functions including regulation of genetic stability,transcription,and protein stability ”1 ”.Recently,tumor suppressors have also been shown to affect the later stages of tumorigenesis,including metastasis.Among this group of metastasis regulators are genes that can directly affect actin dynamics by binding to F-actin,such as the tumor suppressors p53 ”3”,NF2 ”4” and APC ”5”.
F-actin、negative、novel、tumor suppressor、cell proliferation、protein stability、genetic stability、breast cancer、homeostasis、development、regulation、LATS1、range of、control、plays、loss、p53、NF2、APC
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R329.2(人体形态学)
2011-12-23(万方平台首次上网日期,不代表论文的发表时间)
1513-1516