Mark the transition: chromatin modifications and cell fate decision

摘要：

With their unique features of selfrenewal and pluripotency,human embryonic stem (hES) cells are considered to be a nearly unlimited resource for research and clinical applications ”1”.Accordingly,the transcriptional network specifying and governing human ES cell identity has been extensively studied.OCT4,NANOG and SOX2 form a core transcriptional network that regulates itself as well as a number of target genes ”2”.This transcriptional network acts together with signaling pathways to maintain ES cell identity ”3”.Moreover,the last decade has seen tremendous advances in understanding the epigenetic mechanisms underlying ES eell self-renewal and pluripotency.

机标关键词：network、identity、understanding、human、research、features、cells、unique、NANOG、stem、form、hES

所属期刊栏目：21

分类号：R329.2(人体形态学)

在线出版日期：2011-12-23（万方平台首次上网日期，不代表论文的发表时间）

页码：1388-1390