Turning skin into dopamine neurons

摘要：

The possibility to generate neurons from fibroblasts became a reality with the development of iPS technology a few years ago.By reprogramming somatic cells using transcription factor (TF) overexpression,it is possible to generate pluripotent stem cells that then can be differentiated into any somatic cell type including various subtypes of neurons.This raises the possibility of using donor-matched or even patientspecific cells for cell therapy of neurological disorders such as Parkinson”s disease (PD),Huntington”s disease and stroke.Supporting this idea,dopamine neurons,which are the cells dying in PD,derived from human iPS cells have been demonstrated to survive transplantation and reverse motor symptoms in animal models of PD ”1”.

机标关键词：somatic cells、neurological disorders、transcription factor、animal models、development、technology、stem cells、reality、iPS、human、dying、type、idea

所属期刊栏目：21

分类号：R329.2(人体形态学)

在线出版日期：2011-12-23（万方平台首次上网日期，不代表论文的发表时间）

页码：1386-1387