Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2

摘要：

Dear Editor,UHRF1 (ubiquitin-like,containing plant homeodomain (PHD) and RING finger domains,1),also known as ICBP90 in human and NP95 in mouse,is a critical regulator of maintenance of CpG DNA methylation through targeting de novo DNA methyltransferase (DNMT1) to hemimethylated replication forks;its ablation leads to genomic hypomethylation and cell cycle arrest ”1,2”.

机标关键词：domain、PHD、DNA methyltransferase、cell cycle arrest、DNA methylation、maintenance、de novo、human、DNMT1、CpG

所属期刊栏目：21

分类号：R329.2(人体形态学)

资助基金：the National Basic Research Program of China2009CB918600;2011CB965300;the National Natural Science Foundation of China30870493;31030019;11079016;31000325;International Collaboration Program from Science and Technology Commission of Shanghai Municipality10430709300;Fok Ying Tung Education Foundation20090071220012

在线出版日期：2011-12-05（万方平台首次上网日期，不代表论文的发表时间）

页码：1374-1378