Bmil puSHHes reprogramming
In 2006,the group of Shinya Yamanaka demonstrated that somatic cells could be reprogrammed into induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors associated to stemness:Oct4,Sox2,Klf4 and c-Myc ”1”.This groundbreaking discovery opened the possibility of generating patient-specific cells for research,drug development and regenerative medicine.Due to the tremendous potential of its clinical applications,understanding the process of reprogramming has become a priority and one of the most fascinating biomedical research topics.
transcription factors、biomedical research、somatic cells、understanding、development、stem cells、c-Myc、Oct4、Klf4、four
21
R329.2(人体形态学)
2011-12-05(万方平台首次上网日期,不代表论文的发表时间)
1277-1278