Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274

摘要：

Dear Editor, Males-absent-on-the-first (MOF, also called MYST1 or KAT8) is a histone acetyltransferase (HAT) belonging to the MOZ, Ybf2/Sas3, Sas2 and Tip60 (MYST) family.MOF has been shown to possess a specific HAT activity towards Lysl6 of histone H4 (H4K16) ”1”.Homozygous knockout of MOF in mice results in loss of H4K16 acetylation and embryonic lethality, indicating that MOF and H4K16 acetylation are essential for embryogenesis and genome stability in mammals ”2”.Downregulation of human MOF (hMOF) leads to dramatic nuclear morphological deformation and inhibition of cell cycle progression ”3”, and has recently been correlated with primary breast carcinoma and medulloblastoma ”4”.

机标关键词：via、histone acetyltransferase、breast carcinoma、MOF、embryogenesis、cell cycle、essential、results、human、mice、loss

所属期刊栏目：21

分类号：R329.2(人体形态学)

资助基金：This work was supported by MOST2011CB911102;2011CB966301;the National Natural Science Foundation of China30730028;CASSIBS2008002;KSCX2-EW-Q- 1-03;STCSM10JC 1416500

在线出版日期：2011-12-27（万方平台首次上网日期，不代表论文的发表时间）

页码：1262-1266