DNA methylation: a new twist in the tail

摘要：

DNA methylation is the epigenetic mark with the longest history and that we probably understand best, yet we still have no adequate account for why specific DNA sequences are selected to become methylated.Gene-specific DNA methylation is fundamental to processes such as developmental silencing of genes, classical epigenetic phenomena such as genomic imprinting, and occurs pathologically in the silencing of tumor suppressor genes in cancer.Fully understanding the mechanisms of methylation is thus of huge importance.In mammals,the acquisition of DNA methylation is determined by one of two de novo DNA methyltransferase enzymes, Dnmt3a and Dnmt3b.

机标关键词：DNA methylation、tumor suppressor genes、DNA methyltransferase、genomic imprinting、understanding、DNA sequences、acquisition、processes、de novo、account、two

所属期刊栏目：21

分类号：R329.2(人体形态学)

在线出版日期：2011-12-27（万方平台首次上网日期，不代表论文的发表时间）

页码：1155-1156