The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase

摘要：

@@ Dear Editor,Oxygen levels are critical for cellular physiology.Under low oxygen (hypoxia),cells increase glycolysis while limiting mitochondrial oxidative metabolism.Such adaptation is largely mediated by the transcription factors HIF,which accumulate under hypoxia ”1,2”.Prolyl hydroxylase domain proteins (PHD) function as cellular oxygen sensors and target HIF for subsequent degradation under normoxia ”2”.The PHD/HIF pathway is conserved in Drosophila,where a single prolyl hydroxylase,Fatiga,has been characterized.We have previously reported that Fatiga regulates cellular growth rates in a HIF-independent manner,yet mechanisms remained elusive ”3”.

机标关键词：pyruvate kinase、transcription factors、HIF、growth rates、function、PHD、levels、domain、cells

所属期刊栏目：21

分类号：Q255(细胞生理学)

资助基金：the BEST cluster for Bioengineering ETH Zurich;the Roche Research FoundationMkkl/stm 86-2008;the Swiss National Science FoundationPP00A-106737;PP00P3_123359/1-2

在线出版日期：2011-09-08（万方平台首次上网日期，不代表论文的发表时间）

页码：983-986