Mice generated after round spermatid injection into haploid two-cell blastomeres

摘要：

@@ Dear Editor,It is well known that mature oocytes can reprogram somatic nuclei in the process of nuclear transfer(NT)”1”and remodel male gametes in normal fertilization.An intriguing question is whether blastomeres from cleavage-stage embryos retain reprogramming activities.Recently,Egli et al.”2”reported that one blastomere of the twocell-stage embryo can successfully reprogram a donor nucleus, resulting in the formation of an embryonic stem (ES)cell line or a chimeric mouse.

机标关键词：nuclear transfer、nucleus、stem、male、cell

所属期刊栏目：21

分类号：Q959.837(动物学)

资助基金：This work was supported by grants from the Chinese Academy of SciencesKSCX2-YW-R- 110;KSCX2-YW-R-229;XDA01010403;the Ministry of Science and Technology2007CB947101;2009CB941101;National Natural Science Foundation of China30871430;the Shanghai Municipal Commission for Science and Technology07DZ22919;08DJ1400502;09PJ1410900

在线出版日期：2011-07-13（万方平台首次上网日期，不代表论文的发表时间）

页码：854-858