New wrestling rules of anti-inflammatory transrepression by oxysterol receptor LXR revealed
@@ While nuclear receptors(NRs)generally function as transcriptional regulators of diverse metabolic, developmental and proliferative processes, some NRs also appear to modulate inflammatory processes such as those directed by Toll-like receptor(TLR)signaling in macrophages and other cell types of the innate immune system”1,2”.The medical and pharmaceutical interest in these pathways is considerable since NRs are valid drug targets and inflammatoryprocesses have emerged as intrinsic components of metabolic diseases such as obesity, diabetes and atherosclerosis.
LXR、Toll-like receptor、rules of、processes、metabolic diseases、immune system、interest、function、medical、cell、TLR
21
Q71(生物大分子的结构和功能)
2011-07-13(万方平台首次上网日期,不代表论文的发表时间)
711-714