Effective gene silencing in Drosophila ovarian germline by artificial microRNAs

摘要：

@@ Dear Editor,Drosophila oogenesis is of great interest because it represents an excellent model system to study a number of fascinating biological processes, such as stem cell regulation, germ cell meiosis and oocyte determination, as well as signal interactions between germline and soma.A typical Drosophila ovary is composed of 16-20 ovarioles, each consisting of an anterior functional unit called a germarium and a linear string of differentiated egg chambers posterior to the germarium ”1” (Figure 1A and 1B).Drosophila oogenesis initiates at the tip of the germarium, when a germline stem cell (GSC) divides asymmetrically to generate a daughter GSC and a cystoblast that eventually develops into a mature egg ”2” (Figure 1C and 1E).

机标关键词：gene silencing、biological processes、stem cell、model system、interactions、Figure、regulation、interest、typical、GSC、egg、study、tip

所属期刊栏目：21

分类号：Q2(细胞生物学)

资助基金：the National Basic Research Program of China2007CB947502;the National Natural Science Foundation of China91019022;30825026

在线出版日期：2011-07-06（万方平台首次上网日期，不代表论文的发表时间）

页码：700-703